Med Interne. 1980 Jan-Mar;18(1):55-60.

Effect of lithium carbonate on the functional state and the enzymatic equipment of neutrophils in patients with granulocytopenia.

Blicharski J, Aleksandrowicz J, Bodzoń A, Bukasiewicz B, Lisiewicz J.

Abstract

Administration of lithium carbonate, 750 mg daily, during 10 days to 25 patients with essential granulocytopenia, induced an increase of the total leukocyte count, of the absolute count of neutrophils and of the number of neutrophils phagocytizing Staphylococcus aureus Oxford in vitro. An enhancement of acid phosphatase activity in the neutrophils was noted both in the patients and the healthy subjects in the control group. In the patients, the counts of neutrophils exhibiting a positive enzymatic reaction with regard to beta-glucuronidase, myeloperoxidase and alkaline phosphatase were also increased after treatment with lithium carbonate. Based on these results, the authors recommend the clinical application of this treatment in patients with granulocytopenia.

PMID:: 6246567; [PubMed - indexed for MEDLINE]

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[Effect of lithium carbonate on the functional state and enzymatic activity of neutrophils in granulocytopenia]. [Acta Haematol Pol. 1980]
[Effect of lithium carbonate on the functional state and enzymatic activity of neutrophils in granulocytopenia].
Blicharski J, Aleksandrowicz J, Bodzoń A, Bukasiewicz B, Lisiewicz J. Acta Haematol Pol. 1980 Jan-Mar; 11(1):17-23.
Review [Effect of lithium carbonate on the function and enzyme content of the neutrophils in patients with granulocytopenia]. [Folia Med Cracov. 1980]
Review [Effect of lithium carbonate on the function and enzyme content of the neutrophils in patients with granulocytopenia].
Blicharski J, Aleksandrowicz J, Bodzoń A, Bukasiewicz B, Lisiewicz J. Folia Med Cracov. 1980; 22(3-4):367-73.
Lithium carbonate effect on nitrotetrazolium blue (NBT) production in neutrophils of patients with granulocytopenia. [Folia Haematol Int Mag Klin Morphol Blutfor...]
Lithium carbonate effect on nitrotetrazolium blue (NBT) production in neutrophils of patients with granulocytopenia.
Blicharski J, Bodzón A, Lisiewicz J. Folia Haematol Int Mag Klin Morphol Blutforsch. 1981; 108(4):528-32.
[Effect of lithium carbonate on the beta-glucuronidase activity in neutrophils of healthy persons and of patients with neutropenia]. [Patol Pol. 1983]
[Effect of lithium carbonate on the beta-glucuronidase activity in neutrophils of healthy persons and of patients with neutropenia].
Bodzoń A, Król-Grela H. Patol Pol. 1983 Apr-Jun; 34(2):213-9.
Review Attenuation of chemotherapy-induced neutropenia with lithium carbonate. [Am J Hosp Pharm. 1980]
Review Attenuation of chemotherapy-induced neutropenia with lithium carbonate.
Lee M, Hopkins LE. Am J Hosp Pharm. 1980 Aug; 37(8):1066-71.

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Lithium

MW: 6.94 g/mol

MF: Li

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Effect of lithium carbonate on the functional state and the enzymatic equipment of neutrophils in patients with granulocytopenia.

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