Clin Pharmacol Ther. 1980 May;27(5):607-11.

Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets.

Pandey GN, DeLeon-Jones FA, Inwang EE, Davis JM.

Abstract

The effect of acute methadone withdrawal was studied on PGE1-sensitive platelet adenylate cyclase of 8 former heroin addicts who had been stabilized with methadone. During acute methadone withdrawal there was a significant increase in PGE1-sensitive platelet adenylate cyclase activity, which correlated with the severity of withdrawal symptoms. This suggests that PGE1-sensitive adenylate cyclase and cyclic adenosine monophosphate (cyclic AMP) are involved in the human addictive process.

PMID:: 6245830; [PubMed - indexed for MEDLINE]

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Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic ade...
Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets.
Clin Pharmacol Ther. 1980 May ;27(5):607-11.

PubMed
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Effect of acute methadone withdrawal on prostaglandin E-stimulated 3H-cyclic adenosine monophosphate accumulation in human platelets.

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