Nature. 1980 Apr 17;284(5757):601-3.

Selfish genes, the phenotype paradigm and genome evolution.

Abstract

Natural selection operating within genomes will inevitably result in the appearance of DNAs with no phenotypic expression whose only 'function' is survival within genomes. Prokaryotic transposable elements and eukaryotic middle-repetitive sequences can be seen as such DNA's and thus no phenotypic or evolutionary function need be assigned to them.

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