Nature. 1980 Mar 6;284(5751):26-32.

Sequence of the human insulin gene.

Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM.

Abstract

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region. A comparison of the human with the rat insulin genes indicates potential regulatory regions in the DNA segment preceding the gene and suggests that the ancestral form of the insulin gene had two intervening sequences.

PMID:: 6243748; [PubMed - indexed for MEDLINE]

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Sequence of the human insulin gene.

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