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J Biomol Struct Dyn. 1983 Dec;1(4):1011-22.

The lambda and P22 phage repressors.

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  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.


The lambda cI repressor and the P22 c2 repressor contain two structural domains. In both proteins, the N-terminal domains mediate operator recognition and positive control of transcription, and the C-terminal domains mediate subunit oligomerization and recognition of the recA protein. In some cases, structural, biochemical, and genetic studies implicate particular repressor side chains in these processes.

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