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    Am J Med. 1984 Jul 13;77(1A):25-34.

    Safety profile: fifteen years of clinical experience with ibuprofen.

    Royer GL, Seckman CE, Welshman IR.

    Abstract

    Since its introduction in the United States in 1974, ibuprofen (Motrin, Upjohn) has been shown to be safe and effective for the treatment of pain, dysmenorrhea, inflammation, and fever. A careful review of pre-registration and postmarketing data from both patients and normal subjects clearly indicates ibuprofen's remarkable safety profile compared with that of aspirin and other commonly prescribed nonsteroidal anti-inflammatory agents. Continued safety can be anticipated on the basis of the past 15 years of review experience.

    PMID:
    6235745
    [PubMed - indexed for MEDLINE]

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