Format

Send to:

Choose Destination
See comment in PubMed Commons below
Clin Exp Immunol. 1983 Mar;51(3):439-47.

The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK-1.

Abstract

The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by this antibody are almost exclusively confined to germinal centres. Comparison with the distribution of B cells, T cells and T cell subsets underlines the distinctive distribution of these cells for which a physiological role in the maturation of antibody affinity during immune responses is suggested.

PMID:
6221840
[PubMed - indexed for MEDLINE]
PMCID:
PMC1536772
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk