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The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.
We used a cloned human cDNA probe homologous to the placenta chorionic gonadotropin beta subunit (CGB) and to the pituitary luteinizing hormone beta subunit (LHB) and Southern blotting techniques to analyse DNA from a series of rodent X human somatic cell hybrids for the presence of specific gonadotropin beta subunit related sequences. Our results provide evidence for the assignment and linkage of the eight genes (or pseudogenes) coding for the beta subunit of these glycoprotein hormones to chromosome 19. Moreover, we observed a strict concordance between the permissivity of mouse X man hybrid cells to enteroviruses (which is linked to the presence of specific cell receptors encoded by human chromosome 19) and the presence of CGB and LHB related sequences, thus confirming the localization of the structural genes for the beta subunits on chromosome 19.
PMID: 6204923 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.
Lusis AJ, Heinzmann C, Sparkes RS, Scott J, Knott TJ, Geller R, Sparkes MC, Mohandas T.
Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3929-33.
[Proc Natl Acad Sci U S A. 1986]
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Human pregnancy-specific beta 1 glycoprotein is encoded by multiple genes localized on two chromosomes.
Chan WY, Qiu WR.
Am J Hum Genet. 1988 Aug; 43(2):152-9.
[Am J Hum Genet. 1988]
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Expression and regulation of the pituitary- and placenta-specific human glycoprotein hormone alpha-subunit gene is restricted to the pituitary in transgenic mice.
Fox N, Solter D.
Mol Cell Biol. 1988 Dec; 8(12):5470-6.
[Mol Cell Biol. 1988]