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Chromosome assignment of monoclonal antibody-defined determinants on human leukemic cells.
Hybrids formed between human acute lymphoblastic leukemia (ALL) cells and mouse myeloma have been used to determine the chromosomal location of genes required for the expression of several monoclonal antibody (mAb)-defined cell surface antigens on ALL cells. Cloned hybrids were tested for antibody binding, immunoprecipitation of the relevant protein, chromosome isoenzyme markers and karyotype. Two antigens of those studies could be definitively mapped, OKT10/p45 to chromosome 4 and BA-2/p24 to chromosome 12. mAb BA-2 reacts with the same protein as another mAb designated 609-29 (anti-teratocarcinoma). Reactivity with the latter mAb has been previously shown to segregate with chromosome 12.
PMID: 6198179 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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[Purinergic Signal. 2006]
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Molecular and physical arrangements of human DNA in HRAS1-selected, chromosome-mediated transfectants.
Porteous DJ, Morten JE, Cranston G, Fletcher JM, Mitchell A, van Heyningen V, Fantes JA, Boyd PA, Hastie ND.
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[Mol Cell Biol. 1986]
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Expression of human CD antigens, including CD1 and CD25, by human x mouse interlineage leukaemia hybrids.
Taylor GM, Morten H, Carr T, Harrison C, Ridway J, Morris Jones P.
Immunology. 1987 Dec; 62(4):557-65.
[Immunology. 1987]
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