Abstract
From May 1980 to November 1981, 51 consecutive patients with locally advanced, recurrent or metastatic head and neck squamous carcinoma were treated with 2 successive outpatient chemotherapeutic regimens including adriamycin, cyclophosphamide, vincristine, bleomycin, methotrexate and 5-fluorouracil with or without mitomycin-C. A 34% objective response rate was obtained with acceptable toxicity and good patient compliance. The presence of mitomycin-C did not influence response rate. Median survival was 9 months.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / secondary
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Cyclophosphamide / administration & dosage
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Doxorubicin / administration & dosage
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Fluorouracil / administration & dosage
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / pathology
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Head and Neck Neoplasms / secondary
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Humans
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Methotrexate / administration & dosage
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Mitomycin
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Mitomycins / administration & dosage
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Neoplasm Recurrence, Local / drug therapy
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Neoplasm Recurrence, Local / pathology
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Neoplasm Staging
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Time Factors
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Vincristine / administration & dosage
Substances
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Mitomycins
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Bleomycin
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Mitomycin
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Fluorouracil
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Methotrexate