Abstract
The oral LD50 of a compound in hens does not reliably predict the neurotoxic dose of that compound. The oral LD50 in rats does not predict either the oral LD50 in hens or the neurotoxic dose in hens, so there is no justification for using the rat value to predict the neurotoxic dosage in hens. A strategy is presented for a stepwise approach to neurotoxicity testing in hens.
MeSH terms
-
Animals
-
Chemical Phenomena
-
Chemistry
-
Chickens
-
Chlorpyrifos / toxicity
-
Insecticides / toxicity*
-
Isoflurophate / toxicity
-
Leptophos / toxicity
-
Lethal Dose 50
-
Mice
-
Nervous System / drug effects*
-
Organophosphorus Compounds / toxicity*
-
Organothiophosphates / toxicity
-
Organothiophosphorus Compounds / toxicity
-
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / toxicity
-
Prognosis
-
Rats
-
Umbelliferones / toxicity
Substances
-
Insecticides
-
Organophosphorus Compounds
-
Organothiophosphates
-
Organothiophosphorus Compounds
-
Umbelliferones
-
Isoflurophate
-
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester
-
trichloronate
-
butyl phosphorotrithioate
-
Leptophos
-
Chlorpyrifos
-
merphos
-
haloxon