Mol Immunol. 1983 Apr;20(4):483-9.

A computer program for predicting protein antigenic determinants.

Abstract

A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only the amino acid sequence of a protein, and no other information. This procedure has been used to predict the major antigenic determinant of the hepatitis B surface antigen, as well as antigenic sites on a series of test proteins of known antigenic structure [Hopp & Woods (1981) Proc. natn. Acad. Sci. U.S.A. 78, 3824-3828.] The method is suitable for use in smaller personal computers, and is written in the BASIC language, in order to make it available to investigators with limited computer experience and/or resources. A means of locating multiple antigenic sites on a homologous series of proteins is demonstrated using the influenza hemagglutinin as an example.

PMID:: 6191210; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Supplemental Content

Related citations

Prediction of protein antigenic determinants from amino acid sequences. [Proc Natl Acad Sci U S A. 1981]
Prediction of protein antigenic determinants from amino acid sequences.
Hopp TP, Woods KR. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3824-8.
Review Retrospective: 12 years of antigenic determinant predictions, and more. [Pept Res. 1993]
Review Retrospective: 12 years of antigenic determinant predictions, and more.
Hopp TP. Pept Res. 1993 Jul-Aug; 6(4):183-90.
Predicting antigenic determinants of autoantigens. [Autoimmunity. 1990]
Predicting antigenic determinants of autoantigens.
Pollard KM, Cohen MG. Autoimmunity. 1990; 5(4):265-75.
Prediction of strong antigenic determinant of seminalplasmin and ribonuclease from the amino acid sequence. [Int J Pept Protein Res. 1985]
Prediction of strong antigenic determinant of seminalplasmin and ribonuclease from the amino acid sequence.
Pandit MW. Int J Pept Protein Res. 1985 Feb; 25(2):197-9.
Review Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites. [J Immunol Methods. 1986]
Review Protein surface analysis. Methods for identifying antigenic determinants and other interaction sites.
Hopp TP. J Immunol Methods. 1986 Apr 3; 88(1):1-18.

See reviews... See all...

Cited by 32 PubMed Central articles

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections. [PLoS Pathog. 2011]
Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections.
Gnanakaran S, Bhattacharya T, Daniels M, Keele BF, Hraber PT, Lapedes AS, Shen T, Gaschen B, Krishnamoorthy M, Li H, et al. PLoS Pathog. 2011 Sep; 7(9):e1002209. Epub 2011 Sep 29.
Machine learning based prediction for peptide drift times in ion mobility spectrometry. [Bioinformatics. 2010]
Machine learning based prediction for peptide drift times in ion mobility spectrometry.
Shah AR, Agarwal K, Baker ES, Singhal M, Mayampurath AM, Ibrahim YM, Kangas LJ, Monroe ME, Zhao R, Belov ME, et al. Bioinformatics. 2010 Jul 1; 26(13):1601-7. Epub 2010 May 21.
Modelling the human immune system by combining bioinformatics and systems biology approaches. [J Biol Phys. 2006]
Modelling the human immune system by combining bioinformatics and systems biology approaches.
Rapin N, Kesmir C, Frankild S, Nielsen M, Lundegaard C, Brunak S, Lund O. J Biol Phys. 2006 Oct; 32(3-4):335-53. Epub 2006 Oct 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A computer program for predicting protein antigenic determinants.
A computer program for predicting protein antigenic determinants.
Mol Immunol. 1983 Apr ;20(4):483-9.

PubMed
Selective activation of 5HT1A receptors induces lower lip retraction in the rat.
Selective activation of 5HT1A receptors induces lower lip retraction in the rat.
Pharmacol Biochem Behav. 1989 Aug ;33(4):821-7.

PubMed
A SecY homologue is required for the elaboration of the chloroplast thylakoid me...
A SecY homologue is required for the elaboration of the chloroplast thylakoid membrane and for normal chloroplast gene expression.
J Cell Biol. 1998 Apr 20 ;141(2):385-95.

PubMed
The new politics of U.S. health policy.
The new politics of U.S. health policy.
J Health Polit Policy Law. 1997 Apr ;22(2):315-38.

PubMed
Treatment of seasonal affective disorder with a high-output negative ionizer.
Treatment of seasonal affective disorder with a high-output negative ionizer.
J Altern Complement Med. 1995 Jan ;1(1):87-92.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

A computer program for predicting protein antigenic determinants.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

Supplemental Content

Related citations

Cited by 32 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information