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Abnormal immune response to brain tissue antigen in the syndrome of autism.
Cell-mediated immune response to human myelin basic protein was studied by the macrophage migration inhibition factor test in 17 autistic patients and a control group of 11 patients suffering from other mental diseases included in the differential diagnosis of the syndrome of autism. Of the 17 autistic patients, 13 demonstrated inhibition of macrophage migration, whereas none of the nonautistic patients showed such a response. The results indicate the existence of a cell-mediated immune response to brain tissue in the syndrome of autism.
PMID: 6182806 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Molecular mimicry revisited: gut bacteria and multiple sclerosis.
Westall FC.
J Clin Microbiol. 2006 Jun; 44(6):2099-104.
[J Clin Microbiol. 2006]
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Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease.
Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL.
Clin Diagn Lab Immunol. 2004 May; 11(3):515-24.
[Clin Diagn Lab Immunol. 2004]
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Increased frequency of the null allele at the complement C4b locus in autism.
Warren RP, Singh VK, Cole P, Odell JD, Pingree CB, Warren WL, White E.
Clin Exp Immunol. 1991 Mar; 83(3):438-40.
[Clin Exp Immunol. 1991]