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Clin Sci (Lond). 1982 Dec;63(6):519-23.

Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting.


1. Measurements have been made of whole-body and skeletal muscle protein synthesis in fed and fasted adults with L-[1-13C]leucine. 2. The marked increase in whole-body synthesis on feeding largely reflects the changes in protein synthesis in muscle, which doubles on feeding, compared with a 40% increase in that of the rest of the body. 3. Skeletal muscle in fed man contributes more than half to total protein synthesis occurring in the whole body.

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