Proc Natl Acad Sci U S A. 1981 Sep;78(9):5435-9.

DNA sequence of a major human leukocyte interferon gene.

Lawn RM, Gross M, Houck CM, Franke AE, Gray PV, Goeddel DV.

Abstract

The gene for human leukocyte interferon alpha 2 (designated either LeIF A or HuIFN-alpha 2) has been isolated from a human genome library. The DNA sequence of this gene demonstrates that it lacks introns. The 3' noncoding sequences of the IFN-alpha 2 gene correspond to two types of IFN-alpha 2 cDNA clones we have isolated that have alternate sites of polyadenylylation. A comparison of seven human IFN-alpha sequences shows that they are homologous in the 5' flanking region and contain identical "TATA box" sequences. The recombinant lambda clone containing the IFN-alpha 2 gene also contains two copies of the "Alu family" repeat sequence.

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PMCID:: PMC348760

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