Combined antiviral effect of interferon and acyclovir on herpes simplex virus types 1 and 2

Antimicrob Agents Chemother. 1981 Apr;19(4):672-4. doi: 10.1128/AAC.19.4.672.

Abstract

Acyclovir and human interferon displayed an additive to synergistic effect in reducing the number of herpes simplex viral plaque-forming units in Vero cells, suggesting a therapeutic potential for such combination therapy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acyclovir
  • Antiviral Agents / pharmacology*
  • Drug Synergism
  • Guanine / analogs & derivatives*
  • Guanine / pharmacology
  • Interferons / pharmacology*
  • Simplexvirus / drug effects*
  • Viral Plaque Assay

Substances

  • Antiviral Agents
  • Guanine
  • Interferons
  • Acyclovir