Immunologic investigations were carried out with 22 patients with chornic ulcerohemorrhagic colitis in the course of three years. The average values of IgA and TSRFC in the active stage of the disease surpass significantly the normal values. They, to a very large degree, can contribute to the assessment of an advancing remission and in the course of an immunosuppressive treatment the decrease of the therapeutic dosage and the extent to which the patients keep to the prescribed scheme are taken in consideration for its inclusion.