J Cyclic Nucleotide Res. 1980;6(6):451-60.

Mode of action of coronary arterial relaxation by prostacyclin.

Abstract

Subsequent to previous observations suggesting a close association between the relaxing actions of PGI2 and its increasing effects on cyclic AMP levels in bovine coronary smooth muscle, evidence indicative of a transmitter function of cAMP in PGI2-induced relaxation is presented, by showing that a) in time course experiments in circular strips of bovine coronary arteries the increase in cAMP-levels caused by PGI2 preceded the mechanical response, b) the relaxant as well as cAMP-increasing effects produced by PGI2 were significantly potentiated by the PDE-inhibitor MIX, and c) in a particulate preparation of bovine coronary arteries PGI2 concentration dependently stimulated adenylate cyclase in the presence of GTP.

PMID:: 6163806; [PubMed - indexed for MEDLINE]

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Prostacyclin increases cAMP in coronary arteries. [J Cyclic Nucleotide Res. 1979]
Prostacyclin increases cAMP in coronary arteries.
Kukovetz WR, Holzmann S, Wurm A, Pöch G. J Cyclic Nucleotide Res. 1979 Dec; 5(6):469-76.
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Mode of action of coronary arterial relaxation by prostacyclin.
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J Cyclic Nucleotide Res. 1980 ;6(6):451-60.

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Mode of action of coronary arterial relaxation by prostacyclin.

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