Biol Psychiatry. 1980 Dec;15(6):917-23.

Serotoninergic dysfunction in the 47, XYY syndrome.

Bioulac B, Benezech M, Renaud B, Noel B, Roche D.

Abstract

In six XYY patients suffering from aggressiveness and admitted by order of law into a security setting for acts of violence, the estimation of cerebrospinal fluid amine metabolites before and after a probenecid test revealed a clear decrease in the turnover of central serotonin (5-HT) while that of dopamine (DA) was unchanged. The treatment with the 5-HT precursor, L-5-hydroxytryptophan (L-5-HTP), in five of the XYYs resulted in a clinical status equivalent to that observed when the patients were previously treated by conventional neuroleptics.

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Biogenic amines in 47, XYY syndrome. [Neuropsychobiology. 1978]
Biogenic amines in 47, XYY syndrome.
Bioulac B, Benezech M, Renaud B, Roche D, Noël B. Neuropsychobiology. 1978; 4(6):366-70.
[Central metabolism of dopamine and serotonin. I. Determination of cerebrospinal fluid levels of HVA and 5-HIAA by the probenecid test (modified)]. [Acta Neurol (Napoli). 1976]
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Carrieri P, Campanella G, Mandarini A, Orefice G, Buscaino GA. Acta Neurol (Napoli). 1976 Sep-Oct; 31(5):558-64.
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Review Cerebrospinal fluid probenecid studies: a reinterpretation.
Cowdry RW, Ebert MH, van Kammen DP, Post RM, Goodwin FK. Biol Psychiatry. 1983 Nov; 18(11):1287-99.

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Cited by 2 PubMed Central articles

Csf 5 - hiaa in violent and non-violent suicide attempters. [Indian J Psychiatry. 1997]
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