Lancet. 1984 Nov 24;2(8413):1178-80.

Genetic markers in narcolepsy.

Langdon N, Welsh KI, van Dam M, Vaughan RW, Parkes D.

Abstract

Narcolepsy has long been known to have a hereditary familial basis. All of 37 patients with narcolepsy expressed the major histocompatibility complex antigen HLA DR2 compared with 21.5% of 200 normal controls. This finding confirms the genetic basis for the disease, and furthermore links it with the short arm of chromosome 6. If the sleep disturbance in narcolepsy is due to a gene-determined defect in a neurotransmitter or receptor factor, the responsible agent may be DR2 itself or an enzyme determinant linked to DR2. This is the strongest HLA-disease association so far discovered.

PMID:: 6150235; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Medical

narcolepsy - Genetics Home Reference

Supplemental Content

Save items

Related citations in PubMed

HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence. [Sleep. 1986]
HLA antigens in narcolepsy and idiopathic central nervous system hypersomnolence.
Poirier G, Montplaisir J, Décary F, Momège D, Lebrun A. Sleep. 1986; 9(1 Pt 2):153-8.
Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics. [J Clin Invest. 1985]
Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics.
Matsuki K, Juji T, Tokunaga K, Naohara T, Satake M, Honda Y. J Clin Invest. 1985 Dec; 76(6):2078-83.
[HLA and narcolepsy. Apropos of 28 cases including 2 negative HLA-DR2]. [Rev Neurol (Paris). 1988]
[HLA and narcolepsy. Apropos of 28 cases including 2 negative HLA-DR2].
Confavreux C, Gebuhrer L, Betuel H, Freidel C, Bastuji H, Jouvet M, Aimard G, Devic M. Rev Neurol (Paris). 1988; 144(5):327-31.
Review The MHC in human bone marrow allotransplantation. [Clin Haematol. 1983]
Review The MHC in human bone marrow allotransplantation.
Yunis EJ, Awdeh Z, Raum D, Alper CA. Clin Haematol. 1983 Oct; 12(3):641-80.
Review [The HLA system and insulin-dependent diabetes mellitus. A review and personal studies]. [Ann Osp Maria Vittoria Torino....]
Review [The HLA system and insulin-dependent diabetes mellitus. A review and personal studies].
Citro M, Gadaleta G, Gamba Ansaldi S, Molinatti M, Salvetti E, Bruni B. Ann Osp Maria Vittoria Torino. 1983 Jan-Jun; 26(1-6):108-42.

See reviews... See all...

Cited by 12 PubMed Central articles

Review Genome-wide association studies of sleep disorders. [Chest. 2011]
Review Genome-wide association studies of sleep disorders.
Raizen DM, Wu MN. Chest. 2011 Feb; 139(2):446-52.
Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). [PLoS One. 2009]
Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia).
Miyagawa T, Honda M, Kawashima M, Shimada M, Tanaka S, Honda Y, Tokunaga K. PLoS One. 2009; 4(4):e5394. Epub 2009 Apr 30.
Review Clinical and neurobiological aspects of narcolepsy. [Sleep Med. 2007]
Review Clinical and neurobiological aspects of narcolepsy.
Nishino S. Sleep Med. 2007 Jun; 8(4):373-99. Epub 2007 Apr 30.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetic markers in narcolepsy.
Genetic markers in narcolepsy.
Lancet. 1984 Nov 24 ;2(8413):1178-80.

PubMed
An infantile autistic syndrome characterised by the presence of succinylpurines ...
An infantile autistic syndrome characterised by the presence of succinylpurines in body fluids.
Lancet. 1984 Nov 10 ;2(8411):1058-61.

PubMed
Brain stem catecholamine mechanisms in tonic and reflex control of blood pressur...
Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure.
Hypertension. 1984 Sep-Oct ;6(5 Pt 2):II7-15.

PubMed
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
Proc Natl Acad Sci U S A. 1984 Sep ;81(18):5704-8.

PubMed
The interaction of lymphocyte membrane proteins with the lymphocyte cytoskeletal...
The interaction of lymphocyte membrane proteins with the lymphocyte cytoskeletal matrix.
J Immunol. 1984 Nov ;133(5):2767-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Genetic markers in narcolepsy.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 12 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information