Particle size analysis of microcapsules

J Pharm Pharmacol. 1984 Feb;36(2):73-6. doi: 10.1111/j.2042-7158.1984.tb02997.x.

Abstract

To standardize the preparation of three-walled w/o/w microcapsules it was necessary to assess their particle size distribution, since they occur as both unicored and multicored types. The log-normal law, reported to be obeyed by many particulate systems, including microcapsules, was not applicable to the size data. A curve-fitting computer program using least squares minimization was used to assess the size distribution data. The models tested were the unimodal and bimodal log-normal distributions, the bimodal form being the most appropriate. Using the equations to the curves of best fit, the modal size and standard deviation of each population were estimated, and the relative percentages of unicored and multicored microcapsules could be deduced from an analysis of the bimodal curves in which they were represented as the sum of two constituent unimodal distributions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acacia
  • Capsules*
  • Emulsions
  • Particle Size

Substances

  • Capsules
  • Emulsions