Cyproterone acetate in treatment of post-orchidectomy hot flushes. Double-blind cross-over trial

Lancet. 1983 Dec 10;2(8363):1336-7. doi: 10.1016/s0140-6736(83)91092-9.

Abstract

12 patients with troublesome hot flushes after orchidectomy (as a primary treatment for prostatic carcinoma) were treated with cyproterone acetate or placebo in a double-blind cross-over trial. The frequency of hot flushes was significantly reduced during the three weeks that cyproterone acetate (100 mg three times a day) was given. 5 patients complained of lassitude while on cyproterone acetate, but in none was it necessary to discontinue treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Androgen Antagonists / therapeutic use*
  • Castration / adverse effects*
  • Climacteric / drug effects*
  • Clinical Trials as Topic
  • Cyproterone / analogs & derivatives*
  • Cyproterone / therapeutic use
  • Cyproterone Acetate
  • Double-Blind Method
  • Flushing / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Prostatic Neoplasms / therapy
  • Random Allocation

Substances

  • Androgen Antagonists
  • Cyproterone Acetate
  • Cyproterone