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Neuropeptide Y distribution in the rat brain.
A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.
PMID: 6136091 [PubMed - indexed for MEDLINE]
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Cited by 34 PubMed Central articles
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ReviewHungry for life: How the arcuate nucleus and neuropeptide Y may play a critical role in mediating the benefits of calorie restriction.
Minor RK, Chang JW, de Cabo R.
Mol Cell Endocrinol. 2009 Feb 5; 299(1):79-88. Epub 2008 Nov 11.
[Mol Cell Endocrinol. 2009]
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ReviewCaloric restriction: impact upon pituitary function and reproduction.
Martin B, Golden E, Carlson OD, Egan JM, Mattson MP, Maudsley S.
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[Ageing Res Rev. 2008]
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Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus).
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[Horm Behav. 2008]
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