Acta Psychiatr Scand. 1983 May;67(5):339-52.

The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences.

Johnson DA, Pasterski G, Ludlow JM, Street K, Taylor RD.

Abstract

In a prospective follow-up the outcome of 60 chronic schizophrenic patients who discontinued neuroleptic therapy after remaining stable 12-48 months was compared with controls continuing medication. Not only did the drug-discontinued patients have more relapses (P less than 0.001), but the form of relapse was both more severe and acute, resulting in differences of self-injury (P less than 0.05), anti-social behaviour (P less than 0.01), inpatient admissions (P less than 0.001), and the use of compulsory powers (P less than 0.01). In patients who relapsed, both social and work function was affected adversely for some months. Patients who remained relapse-free without drugs (20%) had a level of work and social function similar to medicated patients. At the end of 18 months the patients who discontinued depot maintenance therapy were found to have been prescribed one-third more neuroleptic drugs than controls, with a possible increase in the risk of long-term tardive dyskinesia.

PMID:: 6135298; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Schizophrenia - MedlinePlus Health Information

Molecular Biology Databases

FLUPHENAZINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Clinical and social comparison of fluphenazine decanoate and flupenthixol decanoate in the community maintenance therapy of schizophrenia. [Int Pharmacopsychiatry. 1977]
Clinical and social comparison of fluphenazine decanoate and flupenthixol decanoate in the community maintenance therapy of schizophrenia.
Kelly HB, Freeman HL, Banning B, Schiff AA. Int Pharmacopsychiatry. 1977; 12(1):54-64.
An open clinical trial with the long-acting neuroleptics flupenthixol decanoate and fluphenazine decanoate in the maintenance treatment of schizophrenia. [Pharmatherapeutica. 1989]
An open clinical trial with the long-acting neuroleptics flupenthixol decanoate and fluphenazine decanoate in the maintenance treatment of schizophrenia.
Kong DS, Yeo SH. Pharmatherapeutica. 1989; 5(6):371-9.
A comparative trial of the decanoates of flupenthixol and fluphenazine. [Psychopharmacology (Berl). 1979]
A comparative trial of the decanoates of flupenthixol and fluphenazine.
Hamilton M, Card IR, Wallis GG, Mahmoud MR. Psychopharmacology (Berl). 1979 Aug 8; 64(2):225-9.
Review Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia. [J Psychiatry Neurosci. 1994]
Review Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia.
Midha KK, Hubbard JW, Marder SR, Marshall BD, Van Putten T. J Psychiatry Neurosci. 1994 Jul; 19(4):254-64.
Review [Cost-effectiveness analysis of schizophrenic patient care settings: impact of an atypical antipsychotic under long-acting injection formulation]. [Encephale. 2005]
Review [Cost-effectiveness analysis of schizophrenic patient care settings: impact of an atypical antipsychotic under long-acting injection formulation].
Llorca PM, Miadi-Fargier H, Lançon C, Jasso Mosqueda G, Casadebaig F, Philippe A, Guillon P, Mehnert A, Omnès LF, Chicoye A, et al. Encephale. 2005 Mar-Apr; 31(2):235-46.

See reviews... See all...

Cited by 6 PubMed Central articles

Review Managing suicide risk in patients with schizophrenia. [CNS Drugs. 2011]
Review Managing suicide risk in patients with schizophrenia.
Kasckow J, Felmet K, Zisook S. CNS Drugs. 2011 Feb; 25(2):129-43.
Do antipsychotics limit disability in schizophrenia? A naturalistic comparative study in the community. [Indian J Psychiatry. 2010]
Do antipsychotics limit disability in schizophrenia? A naturalistic comparative study in the community.
Thirthalli J, Venkatesh BK, Naveen MN, Venkatasubramanian G, Arunachala U, Kishore Kumar KV, Gangadhar BN. Indian J Psychiatry. 2010 Jan; 52(1):37-41.
Review Medication-free research in early episode schizophrenia: evidence of long-term harm? [Schizophr Bull. 2006]
Review Medication-free research in early episode schizophrenia: evidence of long-term harm?
Bola JR. Schizophr Bull. 2006 Apr; 32(2):288-96. Epub 2005 Oct 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic p...
The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences.
Acta Psychiatr Scand. 1983 May ;67(5):339-52.

PubMed
Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergi...
Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects.
Mol Pharmacol. 1983 Jan ;23(1):67-70.

PubMed
[Sugar-free diet as long-term or interval treatment in the remission phase of Cr...
[Sugar-free diet as long-term or interval treatment in the remission phase of Crohn disease--a prospective study].
Leber Magen Darm. 1982 Nov ;12(6):225-8.

PubMed
Attempted suicides-35 years afterward.
Attempted suicides-35 years afterward.
Suicide Life Threat Behav. 1977 Summer ;7(2):75-9.

PubMed
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine re...
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.
Lancet. 1983 Jul 9 ;2(8341):98-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The discontinuance of maintenance neuroleptic therapy in chronic schizophrenic patients: drug and social consequences.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 6 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information