Mol Pharmacol. 1983 Jan;23(1):67-70.

Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects.

Huerta-Bahena J, Villalobos-Molina R, García-Sáinz JA.

Abstract

Trifluoperazine and chlorpromazine inhibited in a dose-dependent manner the stimulation of glycogenolysis, gluconeogenesis, and ureogenesis due to alpha 1-adrenergic stimulation in rat hepatocytes. In contrast, the antipsychotic agents were unable to block the inhibition of adenylate cyclase due to alpha 2-adrenergic activation in hamster adipocytes. Binding experiments showed that trifluoperazine and chlorpromazine at low concentrations displaced tritiated dihydroergocryptine binding from rat liver membranes (alpha 1-adrenergic sites), whereas very large concentrations of the phenothiazine derivatives were required to displace dihydroergocryptine from hamster adipocyte membranes (alpha 2-adrenergic sites). It is concluded that chlorpromazine and trifluoperazine are much more potent at alpha 1- than at alpha 2-adrenergic receptors. The use of rat hepatocytes and hamster adipocytes to study the alpha-adrenergic subtype selectivity of drugs is proposed.

PMID:: 6135146; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

RX781094 a potent and selective alpha 2-adrenergic antagonist. Effects in adipocytes and hepatocytes. [Eur J Pharmacol. 1984]
RX781094 a potent and selective alpha 2-adrenergic antagonist. Effects in adipocytes and hepatocytes.
Pushpendran CK, García-Sáinz JA. Eur J Pharmacol. 1984 Apr 6; 99(4):337-9.
Catecholamine binding to the alpha-adrenergic receptors of hamster adipocytes. Evidence that guanine nucleotides regulate this binding to the alpha 2-receptor subtype. [Biochim Biophys Acta. 1982]
Catecholamine binding to the alpha-adrenergic receptors of hamster adipocytes. Evidence that guanine nucleotides regulate this binding to the alpha 2-receptor subtype.
Pecquery R, Giudicelli Y. Biochim Biophys Acta. 1982 Jan 12; 714(1):14-25.
The identification of alpha-adrenergic receptors in adipose tissue by [3H]dihydroergocryptine binding. [Can J Biochem. 1979]
The identification of alpha-adrenergic receptors in adipose tissue by [3H]dihydroergocryptine binding.
Bégin-Heick N, Houlihan PA, Sigouin J. Can J Biochem. 1979 Jul; 57(7):1047-9.
Review Mechanisms involved in alpha-adrenergic effects of catecholamines on liver metabolism. [J Cyclic Nucleotide Res. 1979]
Review Mechanisms involved in alpha-adrenergic effects of catecholamines on liver metabolism.
Exton JH. J Cyclic Nucleotide Res. 1979; 5(4):277-87.
Review Characterization of alpha 1- and alpha 2-adrenergic receptors. [Int Rev Neurobiol. 1983]
Review Characterization of alpha 1- and alpha 2-adrenergic receptors.
Bylund DB, U'Prichard DC. Int Rev Neurobiol. 1983; 24:343-431.

See reviews... See all...

Cited by 1 PubMed Central article

[3H]-idazoxan binds with high affinity to two sites on hamster adipocytes: an alpha 2-adrenoceptor and a non-adrenoceptor site. [Br J Pharmacol. 1989]
[3H]-idazoxan binds with high affinity to two sites on hamster adipocytes: an alpha 2-adrenoceptor and a non-adrenoceptor site.
MacKinnon AC, Brown CM, Spedding M, Kilpatrick AT. Br J Pharmacol. 1989 Dec; 98(4):1143-50.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergi...
Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects.
Mol Pharmacol. 1983 Jan ;23(1):67-70.

PubMed
[Sugar-free diet as long-term or interval treatment in the remission phase of Cr...
[Sugar-free diet as long-term or interval treatment in the remission phase of Crohn disease--a prospective study].
Leber Magen Darm. 1982 Nov ;12(6):225-8.

PubMed
Attempted suicides-35 years afterward.
Attempted suicides-35 years afterward.
Suicide Life Threat Behav. 1977 Summer ;7(2):75-9.

PubMed
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine re...
Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.
Lancet. 1983 Jul 9 ;2(8341):98-9.

PubMed
Effects of beta-adrenoceptor agonists and antagonists on thyroid hormone secreti...
Effects of beta-adrenoceptor agonists and antagonists on thyroid hormone secretion.
Eur J Pharmacol. 1983 Apr 8 ;88(4):383-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information