Natl Cancer Inst Monogr. 1977 Dec;46:125-6.

Chemotherapy of human nervous system tumors: influence on cerebrospinal fluid sterols.

Paoletti P, Pezzotta S, Racca AR, Fumagalli R.

Abstract

The cerebrospinal fluid levels of cholesterol, desmosterol, and the ratio 100 D:C taken from a study of 59 patients are reported. The patients, who had tumors of the nervous system, underwent neurosurgery, radiotherapy, and chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea or 1-(2-chlororethyl)-3-cyclohexyl-1-nitrosourea. The relationships among the levels of these three parameters and the clinical and neuroradiologic evolution are discussed.

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Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain tumors. [Pharmacol Res Commun. 1976]
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