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Science. 1983 Apr 1;220(4592):95-7.

Early morning insomnia with rapidly eliminated benzodiazepines.

Abstract

Early morning insomnia, a significant increase in wakefulness during the final hours of drug nights, occurred after 1 or 2 weeks of nightly administration of benzodiazepine hypnotics with short elimination half-lives, when tolerance had begun to develop. Early morning insomnia may be a variant of rebound insomnia and therefore specific to benzodiazepines, or it may occur with any rapidly eliminated sedative-hypnotic agent.

PMID:
6131538
[PubMed - indexed for MEDLINE]
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