Science. 1983 Mar 11;219(4589):1230-2.

An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons.

Abstract

cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.

PMID:: 6131536; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Bipolar cells in the mudpuppy retina use an excitatory amino acid neurotransmitter. [Nature. 1983]
Bipolar cells in the mudpuppy retina use an excitatory amino acid neurotransmitter.
Slaughter MM, Miller RF. Nature. 1983 Jun 9-15; 303(5917):537-8.
Excitatory amino acid receptors of rod- and cone-driven horizontal cells in the rabbit retina. [J Neurophysiol. 1987]
Excitatory amino acid receptors of rod- and cone-driven horizontal cells in the rabbit retina.
Massey SC, Miller RF. J Neurophysiol. 1987 Mar; 57(3):645-59.
Physiological and pharmacological analysis of suppressive rod-cone interaction in Necturus retina [corrected]. [J Neurophysiol. 1989]
Physiological and pharmacological analysis of suppressive rod-cone interaction in Necturus retina [corrected].
Eysteinsson T, Frumkes TE. J Neurophysiol. 1989 Apr; 61(4):866-77.
Review Amino acid neurochemistry of the vertebrate retina. [Prog Retin Eye Res. 1999]
Review Amino acid neurochemistry of the vertebrate retina.
Kalloniatis M, Tomisich G. Prog Retin Eye Res. 1999 Nov; 18(6):811-66.
Review Electrophysiological studies of drug actions on horizontal cells. [Prog Clin Biol Res. 1982]
Review Electrophysiological studies of drug actions on horizontal cells.
Laufer M. Prog Clin Biol Res. 1982; 13:257-79.

See reviews... See all...

Cited by 25 PubMed Central articles

Glutamate spillover between mammalian cone photoreceptors. [J Neurosci. 2011]
Glutamate spillover between mammalian cone photoreceptors.
Szmajda BA, Devries SH. J Neurosci. 2011 Sep 21; 31(38):13431-41.
Immunocytochemical evidence that monkey rod bipolar cells use GABA. [Eur J Neurosci. 2010]
Immunocytochemical evidence that monkey rod bipolar cells use GABA.
Lassová L, Fina M, Sulaiman P, Vardi N. Eur J Neurosci. 2010 Feb; 31(4):685-96.
Retinal pathway origins of the pattern ERG of the mouse. [Exp Eye Res. 2009]
Retinal pathway origins of the pattern ERG of the mouse.
Miura G, Wang MH, Ivers KM, Frishman LJ. Exp Eye Res. 2009 Jun 15; 89(1):49-62. Epub 2009 Feb 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

An excitatory amino acid antagonist blocks cone input to sign-conserving second-...
An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons.
Science. 1983 Mar 11 ;219(4589):1230-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: