Lancet. 1983 Jan 1;1(8314-5):1-5.

Controlled, randomised trial of the effect of dietary fat on blood pressure.

Puska P, Iacono JM, Nissinen A, Korhonen HJ, Vartianinen E, Pietinen P, Dougherty R, Leino U, Mutanen M, Moisio S, Huttunen J.

Abstract

57 couples living in two communities of North Karelia, aged 30-50 years, were randomly allocated to three groups. After a 2-week baseline period group I followed a diet low in fat (23% of energy) with a high polyunsaturated/saturated (P/S) ratio (1 . 0), group II reduced daily salt intake from 192 mmol to 77 mmol, and group III (control group) continued the usual diet. After the 6-week intervention period groups I and II reverted to their usual diets. In group I systolic blood pressure declined from 138 . 4 to 129 . 5 mm Hg and diastolic blood pressure from 88 . 9 to 81 . 3 mm Hg during the intervention period; the values rose during switch-back. The fall was greater among hypertensive than among normotensive subjects. In groups II and III the mean blood pressure changed very little during the study.

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