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Philos Trans R Soc Lond B Biol Sci. 1981 Jun 26;293(1063):131-43.

Chemistry of proton abstraction by glycolytic enzymes (aldolase, isomerases and pyruvate kinase).


Intermediates have been synthesized that are rapidly utilized by triose phosphate isomerase, yeast aldolase and pyruvate kinase. In each case the compounds have the properties of an enol expected for a stepwise proton transfer mechanism. Apparently the apparatus required for doing this chemistry is sufficiently unique for a large measure of structural homology to have been imposed upon the enzymes of this class during evolution.

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