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    Toxicol Lett. 1981 Mar;7(6):463-7.

    Comparison of sodium and stannous fluoride nephrotoxicity.

    Kassabi M, Braun JP, Burgat-Sacaze V, Bénard P, Rico AG.

    Single i.p. injections of 0.5 mmol F-/kg and repeated i.p. injections of 0.25 mmol F-/kg as NaF or SnF2 to male rats showed that both compounds produced early lesions of kidney tubule demonstrated by an intense increase of urine gamma-glutamyl transferase (GGT). Disturbance of kidney function with an increase of diuresis and phosphaturia and a decrease of natriuria and kaliuria were more marked in SnF2-treated animals as was the decrease of urine GGT after a few days. These results indicate that tin nephrotoxicity adds to that of fluoride and antagonizes tubule regeneration.

    PMID: 6113698 [PubMed - indexed for MEDLINE]

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