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    Nature. 1984 Nov 29-Dec 5;312(5993):465-7.

    Two steroid 21-hydroxylase genes are located in the murine S region.

    White PC, Chaplin DD, Weis JH, Dupont B, New MI, Seidman JG.

    Abstract

    A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC), and is associated in particular with certain allotypes of the HLA-linked complement proteins. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21. The human (HLA) and murine (H-2) MHCs are homologous in overall organization and in the structures of their component genes. To determine whether 21-OH genes are located in the H-2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse. We found that there are two 21-OH genes in this region, located immediately 3' to the C4 and Slp genes.

    PMID:
    6095106
    [PubMed - indexed for MEDLINE]

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