Isolation of cDNA clones encoding the 20K T3 glyco...[Nature. 1984 Nov 29-Dec 5]

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1: Nature. 1984 Nov 29-Dec 5;312(5993):413-8.Links

Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.

van den Elsen P, Shepley BA, Borst J, Coligan JE, Markham AF, Orkin S, Terhorst C.

The complete amino acid sequence of one of the polypeptide chains of the human T3/T-cell receptor complex, the T3 glycoprotein (T3-delta-chain) of relative molecular mass 20,000, was deduced from cDNA clones derived from HPB-ALL cells and a human T-cell clone. Inspection of the 171-amino acid sequence reveals a signal peptide, a 79-amino acid extracellular domain, one transmembrane region and a 44-amino acid intracellular domain which show no sequence homology with members of the T-cell receptor/immunoglobulin/MHC multi-gene family. The T3 delta-chain is coded for by a single-copy gene the expression of which is restricted to T lymphocytes in humans and mice.

PMID: 6095101 [PubMed - indexed for MEDLINE]

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