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J Clin Invest. 1967 Oct;46(10):1589-95.

Brain metabolism during fasting.

Abstract

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.

PMID:
6061736
[PubMed - indexed for MEDLINE]
PMCID:
PMC292907
Free PMC Article
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