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Nature. 1977 Nov 24;270(5635):301-4.

Evolution of ageing.

Abstract

An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's 'error catastrophe' hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.

PMID:
593350
[PubMed - indexed for MEDLINE]
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