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The effect of certain antiplatelet drugs on in vitro malonylaldehyde (MDA) production.
Several antiaggregating agents were tested with regard to their effect on platelet malonylaldehyde (MDA) production which seems to be a good marker of prostaglandin metabolism. Non-steroidal antiinflammatory compounds, namely acetylsalicylic acid (ASA), ditazole and sulfinpyrazone, showed a sure, statistically significant, inhibitory effect on MDA production while theophylline, adenosine and alpha-blocking agent nycergoline did not. Dipyridamole on the contrary, was demonstrated to have a mild but still statistically significant effect on the inhibition of platelet MDA production.
PMID: 583000 [PubMed - indexed for MEDLINE]
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Patient Drug Information
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Theophylline (Bronkodyl® , Elixophyllin® , Slo-bid® , ...)
Theophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases. It relaxes and opens air passages in the lungs, ...
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Dipyridamole (Persantine® )
Dipyridamole is used with other drugs to reduce the risk of blood clots after heart valve replacement. It works by preventing excessive blood clotting.
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Clopidogrel (Plavix, Ticlid, Persantine, ...)
How do antiplatelet agents compare in acute coronary syndromes?
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