Iatrogenic epilepsy due to antidepressant drugs

Br Med J. 1969 Oct 11;4(5675):80-2. doi: 10.1136/bmj.4.5675.80.

Abstract

AN ANALYSIS OF THE CASE HISTORIES OF NINE PATIENTS WHO DEVELOPED EPILEPTIC FITS SHORTLY AFTER STARTING TRICYCLIC ANTIDEPRESSANT DRUGS SHOWED THAT ALL OF THEM HAD ONE OR MORE OF THE FOLLOWING FACTORS: previous or family history of epilepsy, pre-existing brain damage, cerebral arteriosclerosis, alcoholism, withdrawal of barbiturates, and history of previous electric convulsive therapy. Before prescribing antidepressant drugs these factors should be sought for in the history, and if any are present prophylactic anticonvulsant medication is indicated. From a limited experience we do not think that chlordiazepoxide is adequate to counteract the convulsant effect of antidepressant drugs.

MeSH terms

  • Adolescent
  • Adult
  • Alcoholism / complications
  • Amitriptyline / adverse effects
  • Antidepressive Agents / adverse effects*
  • Barbiturates
  • Brain Damage, Chronic / complications
  • Cerebrovascular Disorders / complications
  • Electroconvulsive Therapy
  • Epilepsy / chemically induced*
  • Female
  • Humans
  • Imipramine / adverse effects
  • Male
  • Middle Aged
  • Perphenazine / adverse effects
  • Substance Withdrawal Syndrome / complications

Substances

  • Antidepressive Agents
  • Barbiturates
  • Amitriptyline
  • Perphenazine
  • Imipramine