Abstract
Clofibrate-related compounds were synthesized from substituted phenoxyacetic acids by esterification with salicylic acid derivatives, by amidation of thiazolidines or by reaction with cinnarizine. Lipid lowering effect was investigated in normolipemic and hyperlipemic rats. The long-term hyperlipemic model used permits differentiation of hypolipemic efficacy, i.e., from clofibrate or compounds of similar activity.
MeSH terms
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Animals
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Cholesterol / blood
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Cinnarizine / pharmacology
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Clofibrate* / analogs & derivatives*
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Clofibrate* / pharmacology
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Clofibrate* / toxicity
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Dietary Fats
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Drug Evaluation, Preclinical
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Female
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Guinea Pigs
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Hypolipidemic Agents*
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Lethal Dose 50
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Mice
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Rats
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Salicylates / pharmacology
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Thiazoles / pharmacology
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Time Factors
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Triglycerides / blood
Substances
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Dietary Fats
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Hypolipidemic Agents
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Salicylates
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Thiazoles
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Triglycerides
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Cinnarizine
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Cholesterol
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Clofibrate