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    Arzneimittelforschung. 1979;29(9a):1475-7.

    Protective effect of creatinol O-phosphate (COP) on some experimental arrhythmias in vitro and in vivo.

    Ferrini R, Miragoli G.

    The activity of N-methyl-N-(beta-hydroxyethyl)guanidine O-phosphate (creatinol O-phosphate, COP) on two in vitro and in vivo experimental arrhythmias was investigated. The substance proved to be active in delaying the onset time of aconitine induced arrhythmias in guinea-pig atria. COP showed also a definite antagonizing activity against chloroform-induced ventricular fibrillation in mice.

    PMID: 575497 [PubMed - indexed for MEDLINE]

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