Science. 1968 Nov 29;162(3857):1007-9.

Activation of Hageman factor by L-homocystine.

Abstract

L-Homocystine activates Hageman factor, as demonstrated by its capacity to initiate clotting and to induce the evolution of plasma kinins. Perhaps, strategically located deposits of this amino acid are responsible for the unusual frequency of thrombosis in patients with homocystinuria.

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Review Molecular assembly in the contact phase of the Hageman factor system. [Am J Med. 1979]
Review Molecular assembly in the contact phase of the Hageman factor system.
Cochrane CG, Griffin JH. Am J Med. 1979 Oct; 67(4):657-64.
Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor. [Proc Natl Acad Sci U S A. 1976]
Mechanisms for the involvement of high molecular weight kininogen in surface-dependent reactions of Hageman factor.
Griffin JH, Cochrane CG. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2554-8.
Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein. [J Exp Med. 1973]
Activation of Hageman factor in solid and fluid phases. A critical role of kallikrein.
Cochrane CG, Revak SD, Wuepper KD. J Exp Med. 1973 Dec 1; 138(6):1564-83.
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Review Factor XI and XII as antithrombotic targets.
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Review Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response. [J Allergy Clin Immunol. 1975]
Review Activation and control mechanisms of Hageman factor-dependent pathways of coagulation, fibrinolysis, and kinin generation and their contribution to the inflammatory response.
Kaplan AP, Austen KF. J Allergy Clin Immunol. 1975 Dec; 56(6):491-506.

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Cited by 5 PubMed Central articles

Homocystinuria. [Proc R Soc Med. 1970]
Homocystinuria.
Carson NA. Proc R Soc Med. 1970 Jan; 63(1):41-3.
A prealbumin activator of prekallikrein. 3. Appearance of chemotactic activity for human neutrophils by the conversion of human prekallikrein to kallikrein. [J Exp Med. 1972]
A prealbumin activator of prekallikrein. 3. Appearance of chemotactic activity for human neutrophils by the conversion of human prekallikrein to kallikrein.
Kaplan AP, Kay AB, Austen KF. J Exp Med. 1972 Jan; 135(1):81-97.
Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors. [J Clin Invest. 1969]
Studies on a complex mechanism for the activation of plasminogen by kaolin and by chloroform: the participation of Hageman factor and additional cofactors.
Ogston D, Ogston CM, Ratnoff OD, Forbes CD. J Clin Invest. 1969 Oct; 48(10):1786-801.

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Activation of Hageman factor by L-homocystine.

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