Proc Natl Acad Sci U S A. 1976 May;73(5):1693-7.

Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation.

DeMars R, LeVan SL, Trend BL, Russell LB.

Abstract

Mice with the X-chromosomal sparse-fur (spf) mutation frequently have urinary bladder stones composed mostly of orotic acid, which was identified by the following criteria: ultraviolet and infrared absorption, spectra, chromatographic behavior, melting point, and reactivity in a specific color test. This clue led to the discovery that spf-bearing mice have an abnormal form of liver ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase, EC 2.1.3.3). Normal ornithine carbamoyltransferase has maximum activity at pH 7.6-8.0 and 80% of maximum activity at pH 10.0.

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Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation.
Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation.
Proc Natl Acad Sci U S A. 1976 May ;73(5):1693-7.

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Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation.

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