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Dig Dis Sci. 1979 Mar;24(3):221-4.

Discordance for achalasia in identical twins.

Abstract

Twenty-year-old twin sisters, believed monozygotic on the basis of extensive blood grouping and cytogenetic studies, are reported. One twin demonstrated classical clinical, radiologic, and manometric features of achalasia, while similar studies in her sister documented perfectly normal esophageal motor function. Genetically determined damage to the esophageal parasympathetic innervation is, therefore, not a likely cause for the esophageal motor dysfunction in achalasia.

PMID:
572288
[PubMed - indexed for MEDLINE]
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