Neurology. 1978 Jan;28(1):64-70.

Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine.

Hardebo JE, Edvinsson L, Owman C, Svendgaard NA.

Abstract

The vasoconstrictor action of serotonin and its interaction with drugs (methysergide, pizotifen, cyproheptadine, ergotamine, dihydroergotamine) that have serotonin-antagonistic properties and that are used in the treatment of migraine were studied on isolated feline and human intracranial and extracranial arteries in vitro. The intracranial vessels were more sensitive to serotonin than the extracranial ones. The serotonin antagonists caused the expected impairment of the serotonin-induced contraction. In minute doses, the various compounds potentiated the contraction produced by serotonin. There is reason to believe that the mechanism responsible for this interaction is selective for tryptaminergic agents. This dual action of the serotonin antagonists may contribute to a beneficial effect in migraine by an interference during both the vasoconstrictory and vasodilatory phase.

PMID:: 563539; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Review [Serotonin agonists and antagonists in migraine]. [Pathol Biol (Paris). 1992]
Review [Serotonin agonists and antagonists in migraine].
Ollat H. Pathol Biol (Paris). 1992 Apr; 40(4):389-96.
[Serotonin and antiserotonergic agents]. [Rev Prat. 1990]
[Serotonin and antiserotonergic agents].
Bourin M. Rev Prat. 1990 Jun 21; 40(18):1711-3.
[Mechanism of action of drugs currently used in the prevention of migraine]. [Minerva Med. 1976]
[Mechanism of action of drugs currently used in the prevention of migraine].
Fanchamps A. Minerva Med. 1976 Jun 2; 67(28):1858-60.
Review The animal pharmacology of drugs used in the treatment of migraine. [J Pharm Pharmacol. 1975]
Review The animal pharmacology of drugs used in the treatment of migraine.
Fozard JR. J Pharm Pharmacol. 1975 May; 27(5):297-321.
Comparative effects of noradrenaline and serotonin in a central and a peripheral artery in vitro. [Afr J Med Med Sci. 1983]
Comparative effects of noradrenaline and serotonin in a central and a peripheral artery in vitro.
Tayo FM. Afr J Med Med Sci. 1983 Sep-Dec; 12(3-4):139-43.

See reviews... See all...

Cited by 5 PubMed Central articles

Vascular smooth muscle response to fibrinogen degradation products and 5-hydroxytryptamine: possible role in cerebral vasospasm in man. [Br J Clin Pharmacol. 1980]
Vascular smooth muscle response to fibrinogen degradation products and 5-hydroxytryptamine: possible role in cerebral vasospasm in man.
Forster C, Whalley ET, Mohan J, Dutton J. Br J Clin Pharmacol. 1980 Sep; 10(3):231-6.
Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts. [Br J Pharmacol. 1981]
Proceedings of the British Pharmacological Society. 10th-12th September, 1980. Abstracts.
. Br J Pharmacol. 1981 Mar; 72(3):487P-590P.
Calcium channel antagonism by pizotifen. [J Neurol Neurosurg Psychiatry....]
Calcium channel antagonism by pizotifen.
Peroutka SJ, Banghart SB, Allen GS. J Neurol Neurosurg Psychiatry. 1985 Apr; 48(4):381-3.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Potentiation and antagonism of serotonin effects on intracranial and extracrania...
Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine.
Neurology. 1978 Jan ;28(1):64-70.

PubMed
Chronic urticaria. A clinical study of fifty patients.
Chronic urticaria. A clinical study of fifty patients.
Am J Med. 1968 Jan ;44(1):68-86.

PubMed
Diurnal variation of prednisolone binding to serum corticosteroid-binding globul...
Diurnal variation of prednisolone binding to serum corticosteroid-binding globulin in man.
Clin Pharmacol Ther. 1978 Jan ;23(1):47-53.

PubMed
[On the occurrence of M. avium in other domestic animals than poultry, especiall...
[On the occurrence of M. avium in other domestic animals than poultry, especially in cattle and swine].
Z Tuberk Erkr Thoraxorg. 1967 ;127(1):109-10.

PubMed
Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the ...
Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon.
Appl Environ Microbiol. 1977 Nov ;34(5):529-33.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Potentiation and antagonism of serotonin effects on intracranial and extracranial vessels. Possible implications in migraine.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 5 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information