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J Clin Pathol. 1970 Dec;23(9):781-3.

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia.

Abstract

A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0.1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.

PMID:
5504372
[PubMed - indexed for MEDLINE]
PMCID:
PMC476897
Free PMC Article
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