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Appl Microbiol. 1970 Aug;20(2):215-7.

Product inhibition of the fermentative formation of glutamic acid.

Abstract

The addition of penicillin to cells of Corynebacterium glutamicum growing in 5-liter fermentors initiated the excretion of glutamic acid. The rate of glutamate production in fermentors declined continuously with time and reached 75% of the initial rate in 24 hr after penicillin had been added. The addition of glutamate to resting cell suspensions had only a slight effect on sugar utilization but caused a marked decrease in glutamate excretion. It is suggested that the high level of glutamate accumulating in the fermentation broth is responsible for inhibiting its own production.

PMID:
5480097
[PubMed - indexed for MEDLINE]
PMCID:
PMC376903
Free PMC Article
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