The effect of cardiac disease on hemoglobin-oxygen binding

J Clin Invest. 1970 Jul;49(7):1349-56. doi: 10.1172/JCI106351.

Abstract

The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O(2)) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]V(VO2)) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.

MeSH terms

  • Adenosine Triphosphate / blood
  • Adult
  • Aged
  • Binding Sites*
  • Cardiac Catheterization
  • Cardiac Output
  • Erythrocytes / metabolism
  • Female
  • Glycerophosphates / blood
  • Heart / physiopathology*
  • Heart Diseases / blood*
  • Heart Diseases / physiopathology
  • Hemoglobins / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Oxygen / blood*
  • Oxygen Consumption

Substances

  • Glycerophosphates
  • Hemoglobins
  • Adenosine Triphosphate
  • Oxygen