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Science. 1970 Feb 6;167(3919):871-3.

Cystic fibrosis: characterization of the inhibitor to ciliary action in oyster gills.


The inhibitor to oyster ciliary activity was isolated from serumof cystic fibrosis patients and heterozygotes. The inhibitinig protein fraction wast a cation as judged by electrophoresis; it had a molecuer weight of 125,000 to 200,000 as judged by gel filtration; antd oil diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster cillary activity.

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