Toxicology. 1979 Oct;14(2):117-30.

Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits.

Murphy JC, Watson ES, Wirth PW, Skierkowski P, Folk RM, Peck G.

Abstract

Of 30 antineoplastic agents studied for their primary irritation potential in rabbits, 9 showed some potential for irritation. Five of these 9 agents produced a significant dermal irritation. None of the irritation observed was considered to be irreversible skin damage. The study further showed a strong correlation between irritation observed by the Draize method and acute inflammation evaluated histopathologically. There was a tendency toward increased epidermal thickness of irritated skin sites. None of the agents produced gross or microscopically visible lesions in the internal organs observed.

PMID:: 538765; [PubMed - indexed for MEDLINE]

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Cutaneous irritation in the topical application of 30 antineoplastic agents to N...
Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits.
Toxicology. 1979 Oct ;14(2):117-30.

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Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits.

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