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1: Lancet. 1975 Oct 18;2(7938):748-9.Click here to read Links

Chronic pancreatitis and alpha-1-antitrypsin.

Novis BH, Young GO, Bank S, Marks IN.

110 patients with proven chronic pancreatitis have been studied to assess the prevalence of the various Pi phenotypes of alpha1-antitrypsin in this disease compared with a control group of 116 blood-donors. The phenotype PiMZ (including Mweak) was significantly more prevalent and PiMM significantly less so in the patients with pancreatitis. It is possible that a heterozygous deficiency of this protease inhibitor renders the pancreas more vulnerable to aetiological agents (e.g., alcohol).

PMID: 52776 [PubMed - indexed for MEDLINE]