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Proc Natl Acad Sci U S A. 1969 Feb;62(2):597-603.

Deoxyribonuclease IV: a new exonuclease from mammalian tissues.

Abstract

An exonuclease which specifically degrades double-standard DNA has been isolated from rabbit tissues. The enzyme has an approximate molecular weight of 42,000, requires a divalent metal ion as cofactor, and attacks DNA at the 5'-terminal ends, thereby liberating 5'-mononucleotides. It degrades several synthetic polydeoxynucleotides of single repeating base sequences more rapidly than DNA from natural sources. The specificity of this mammalian enzyme resembles that of several microbial enzymes (phage lambda exonuclease and DNA polymerase) which appear to be required for repair and recombination of DNA.

PMID:
5256235
[PubMed - indexed for MEDLINE]
PMCID:
PMC277851
Free PMC Article
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